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A recent study has demonstrated that the combined detection of ADHFE1/SDC2/PPP2R5C methylation could potentially be used as a non-invasive diagnostic approach for CRC and screening for precancerous lesions (Li et al., 2023)

This ultrasound-triggered metabolic intervention not only suppressed primary tumor growth but also enhanced systemic antitumor immunity when combined with -PD-1 therapy, leading to pronounced inhibition of both local and distant tumors

Antibodies binding to and directly stimulating the IGF-1R have also been proposed to play a role in this process

In this article, we review the history of DSIP, discuss what researchers currently understand about how it may work, and highlight the limitations of existing research